Neurobion Forte soln for inj: Vitamins B1, B6 and B12 (NEUROBION Forte) must not be used in patients hypersensitive to any of the active ingredients or excipients of the product. This product should not be given to children below 14 years of age.
Special Precautions
Neurobion tab, Neurobion Forte tab: Neuropathies are described in the literature following long-term intake (6-12 months) of more than 50 mg mean daily dose of vitamin B6. Therefore, regular monitoring is recommended under long-term treatment.
In individual cases, high doses of vitamin B6, i.e. > 600 mg daily, may inhibit the production of breast milk.
No effects of the product on the ability to drive or use machines are known.
Neurobion tab: Before taking the tablet, please ensure that it was stored in a cool dry place, not exceeding 25°C. The packaging should not be severely damaged at the time of purchase as there might be danger of product degradation or exposure to contaminants.
Vitamins B1 + B6 + B12 (NEUROBION) tablet contains lactose and sucrose; therefore its use is not recommended in patients with rare hereditary galactose or fructose intolerance, glucose-galactose malabsorption, Lapp lactase deficiency, or sucrase-isomaltase insufficiency.
Take Vitamins B1 + B6 + B12 (NEUROBION) tablet only as recommended or as supervised by a physician.
Neurobion Forte tab: Before the patient takes the tablet, please ensure that it was stored in a cool dry place, not exceeding 30°C. The packaging should not be severely damaged at the time of purchase as there might be danger of product degradation or exposure to contaminants.
Vitamins B1 + B6+ B12 (NEUROBION Forte) tablet contains lactose and sucrose; therefore its use is not recommended in patients with rare hereditary galactose or fructose intolerance, glucose-galactose malabsorption, Lapp lactase deficiency, or sucrase-isomaltase insufficiency.
Take Vitamins B1 + B6+ B12 (NEUROBION Forte) tablet only as recommended or as supervised by a physician.
Neurobion Forte soln for inj: In the literature, neuropathies are described under long-term intake (6-12 months) of more than 50 mg mean daily dose of vitamin B6. Therefore, under long-term treatment, regular monitoring is recommended.
Do not re-use syringes and needles. Syringes and needles must be disposed immediately after use. Used syringes and needles must not be disposed in waste bins or toilets, but they must be disposed in a special sharps container.
This medication is used to treat lack or deficiency of vitamins when the form taken by mouth cannot be used or would not work as well as the injection.
Do not share this medication with others. This product is not a substitute for a proper diet. Remember that it is best to get vitamins from healthy foods.
In individual cases, high doses of vitamin B6, i.e. > 600 mg daily, may inhibit the production of breast milk.
No effects of the product on the ability to drive or use machines are known.
Neurobion tab: Before taking the tablet, please ensure that it was stored in a cool dry place, not exceeding 25°C. The packaging should not be severely damaged at the time of purchase as there might be danger of product degradation or exposure to contaminants.
Vitamins B1 + B6 + B12 (NEUROBION) tablet contains lactose and sucrose; therefore its use is not recommended in patients with rare hereditary galactose or fructose intolerance, glucose-galactose malabsorption, Lapp lactase deficiency, or sucrase-isomaltase insufficiency.
Take Vitamins B1 + B6 + B12 (NEUROBION) tablet only as recommended or as supervised by a physician.
Neurobion Forte tab: Before the patient takes the tablet, please ensure that it was stored in a cool dry place, not exceeding 30°C. The packaging should not be severely damaged at the time of purchase as there might be danger of product degradation or exposure to contaminants.
Vitamins B1 + B6+ B12 (NEUROBION Forte) tablet contains lactose and sucrose; therefore its use is not recommended in patients with rare hereditary galactose or fructose intolerance, glucose-galactose malabsorption, Lapp lactase deficiency, or sucrase-isomaltase insufficiency.
Take Vitamins B1 + B6+ B12 (NEUROBION Forte) tablet only as recommended or as supervised by a physician.
Neurobion Forte soln for inj: In the literature, neuropathies are described under long-term intake (6-12 months) of more than 50 mg mean daily dose of vitamin B6. Therefore, under long-term treatment, regular monitoring is recommended.
Do not re-use syringes and needles. Syringes and needles must be disposed immediately after use. Used syringes and needles must not be disposed in waste bins or toilets, but they must be disposed in a special sharps container.
This medication is used to treat lack or deficiency of vitamins when the form taken by mouth cannot be used or would not work as well as the injection.
Do not share this medication with others. This product is not a substitute for a proper diet. Remember that it is best to get vitamins from healthy foods.
Use In Pregnancy & Lactation
Neurobion Forte soln for inj: No risks have become known associated with the use Vitamins B1 + B6 + B12 (NEUROBION Forte) during pregnancy at the recommended dosage.
Vitamins B1, B6 and B12 are secreted into human breast milk, but risks of overdose for the infant are not known. In individual cases, high doses of vitamin B6 (i.e. >600 mg daily), may inhibit the production of breast milk.
Vitamins B1, B6 and B12 are secreted into human breast milk, but risks of overdose for the infant are not known. In individual cases, high doses of vitamin B6 (i.e. >600 mg daily), may inhibit the production of breast milk.
Adverse Reactions
Immune system disorders: Hypersensitivity reactions, such as sweating, tachycardia, and skin reactions with itching and urticaria. In single cases, conditions of shock have been observed after treatment with vitamin B1 or B12 injections.
Gastrointestinal disorders: Gastrointestinal complaints, such as nausea, vomiting, diarrhea and abdominal pain.
Renal and urinary disorders: Chromaturia (“reddish urine” appears during the first 8 hours after an administration and typically resolves within 48 hours).
Stop taking this product and consult with a physician if the above effects are observed.
Gastrointestinal disorders: Gastrointestinal complaints, such as nausea, vomiting, diarrhea and abdominal pain.
Renal and urinary disorders: Chromaturia (“reddish urine” appears during the first 8 hours after an administration and typically resolves within 48 hours).
Stop taking this product and consult with a physician if the above effects are observed.
View ADR Monitoring Form
Drug Interactions
Vitamin B6 (pyridoxine) may decrease the effect of L-DOPA.
Pyridoxine antagonists such as isoniazid, cycloserine, penicillamine, or hydralazine may decrease the efficacy of vitamin B6 (pyridoxine).
Long-term use of loop diuretics such as furosemide may accelerate the elimination and thus decrease the serum levels of vitamin B1 (thiamine).
Long-term use of acid-lowering agents may lead to vitamin B12 deficiency.
Pyridoxine antagonists such as isoniazid, cycloserine, penicillamine, or hydralazine may decrease the efficacy of vitamin B6 (pyridoxine).
Long-term use of loop diuretics such as furosemide may accelerate the elimination and thus decrease the serum levels of vitamin B1 (thiamine).
Long-term use of acid-lowering agents may lead to vitamin B12 deficiency.
Caution For Usage
Neurobion Forte soln for inj: Incompatibilities: It is not recommended to use Vitamins B1 + B6 + B12 (Neurobion Forte) solution for injection together with other medicinal products in a “mixed injection” or infusion.
Vitamin B1 is completely degraded by sulfite-containing infusion solutions.
Other vitamins, especially cyanocobalamin, may be inactivated in the presence of Vitamin B degradation products.
Vitamin B1 is completely degraded by sulfite-containing infusion solutions.
Other vitamins, especially cyanocobalamin, may be inactivated in the presence of Vitamin B degradation products.
Storage
Neurobion tab: Store at temperatures not exceeding 25°C.
Neurobion Forte tab, Neurobion Forte soln for inj: Store at temperatures not exceeding 30°C.
Neurobion Forte tab, Neurobion Forte soln for inj: Store at temperatures not exceeding 30°C.
MIMS Class
ATC Classification
A11DB – Vitamin B1 in combination with vitamin B6 and/or vitamin B12 ; Used as dietary supplements.